You will submit a concept map exploring the four agonists on the agonist spectrum (agonist, partial agonist, antagonist, and inverse agonist) in which you:
- Describe the different characteristics of the four agonists and how each mediates distinct biological activities. Include proposed mechanisms and the receptor it is targeting.
- Identify how the P450 enzyme system plays a role in the body’s absorption, distribution, and clearance of medication.
- Scavenge the literature after describing each agonist on the spectrum for research that is based on the medications in the table below.
- Apply the medications to the appropriate agonist on the agonist spectrum in your Concept Map.
Medications
Oxycodone
Brexpiprazole
Haloperidol
Naloxone
Aripiprazole
Amphetamine
Risperidone
Pimavanserin
Assignment_Rubric
Assignment_Rubric
CriteriaRatingsPts
This criterion is linked to a Learning OutcomeConcept map explains the four agonists on the agonist spectrum according to different characteristics and mediation of biological activities. Concept map explains the proposed mechanism and receptor it is targeting. Identifies how the P450 enzyme system plays a role in the body’s absorption, distribution, and clearance of medication.
50 to >36.0 pts
Excellent
The response comprehensively and clearly explains each of the four agonists on the agonist spectrum according to different characteristics and mediation of biological activities. Identifies how the P450 enzyme system plays a role in the body’s absorption, distribution, and clearance of medication. The response comprehensively and clearly explains the proposed mechanism and receptor it is targeting.
36 to >24.0 pts
Good
The response clearly explains each of the four agonists on the agonist spectrum but is not comprehensive according to different characteristics and mediation of biological activities. . Identifies how the P450 enzyme system plays a role in the body’s absorption, distribution, and clearance of medication; but is not comprehensive. The response clearly explains the proposed mechanism and receptor it is targeting but is not comprehensive.
24 to >11.0 pts
Fair
The response inaccurately or vaguely explains each of the four agonists on the agonist spectrum or only discusses three out of the four agonists. The response inaccurately or vaguely explains the proposed mechanism and/or receptor it is targeting. Vaguely or inaccurately identifies how the P450 enzyme system plays a role in the body’s absorption, distribution, and clearance of medication.
11 to >0 pts
Poor
The response inaccurately or vaguely explains two out of four agonists on the agonist spectrum, or the response is missing. The response includes inaccurate and vague examples that do not explain the proposed mechanism and receptor it is targeting, or it is missing. Does not identify how the P450 enzyme system plays a role in the body’s absorption, distribution, and clearance of medication.
50 pts
This criterion is linked to a Learning OutcomeThe eight (8) medications provided in the Assignment list are applied to the appropriate agonist on the agonist spectrum.
30 to >21.0 pts
Excellent
All eight (8) of the medications are accurately applied to the correct agonist on the agonist spectrum.
21 to >12.0 pts
Good
Six to seven (6–7) of the medications are accurately applied to the correct agonist on the agonist spectrum.
12 to >6.0 pts
Fair
Four to five (4–5) of the medications are accurately applied to the correct agonist on the agonist spectrum.
6 to >0 pts
Poor
Less than three (3) of the medications are accurately applied to the correct agonist on the agonist spectrum.
30 pts
This criterion is linked to a Learning OutcomeThe concept map is correctly designed and includes creative visual aids.
10 to >7.0 pts
Excellent
The concept map accurately portrays a concept map design and includes two (2) or more creative visual aids.
7 to >4.0 pts
Good
The concept map accurately portrays a concept map design and includes less than two (2) creative visual aids.
4 to >1.0 pts
Fair
The concept map accurately portrays a concept map design with no inclusion of creative and visual aids.
1 to >0 pts
Poor
The submission does not accurately portray a concept map design.
10 pts
This criterion is linked to a Learning OutcomeWritten Expression and Formatting—English writing standards: Correct grammar, mechanics, and proper punctuation
5 to >4.0 pts
Excellent
Uses correct grammar, spelling, and punctuation with no errors.
4 to >3.0 pts
Good
Contains a few (one or two) grammar, spelling, and punctuation errors.
3 to >1.0 pts
Fair
Contains several (three or four) grammar, spelling, and punctuation errors.
1 to >0 pts
Poor
Contains many (five or more) grammar, spelling, and punctuation errors that interfere with the reader’s understanding.
5 pts
This criterion is linked to a Learning OutcomeWritten Expression and Formatting: The submission contains an APA format for title page, citations, and reference list.
5 to >4.0 pts
Excellent
Uses correct APA format for title page, citations, and reference list with no errors.
4 to >3.0 pts
Good
Contains one or two APA format errors with title page, citations, and reference list.
3 to >1.0 pts
Fair
Contains three or four APA format errors with title page, citations, and reference list.
1 to >0 pts
Poor
Missing APA format title page, citations, and/or reference list.
5 pts
Total Points: 100