After reading Chapter 2 (pages 25-27) in your ebook, discuss how pharmacogenomics affects drug response in people. Also, construct a concept map to illustrate how pharmacogenomics affects drug response in people with various illnesses. Use the articles attached below to support your response.
Pharmacogenetics of Drugs Used in the Treatment of Cancers
How to Make a Concept Map: Beginner’s Guide (& Templates)
Instructions:
Your discussion post should be at least 140 words and include at least one 100-word response to a classmate. Follow APA guidelines for references. At least one reference is required to support your response. To see the grading rubric, click on the 3-dot menu on the top-right side of screen.
Pharmacogenomics is the study of how an individual’s genetic makeup influences their response to drugs. It examines how genetic variations can affect drug efficacy, toxicity, and overall treatment outcomes. By understanding a person’s genetic profile, healthcare professionals can tailor drug therapy to maximize effectiveness and minimize adverse reactions.
Several factors contribute to the influence of pharmacogenomics on drug response. Genetic variations can impact drug metabolism, drug targets, and drug transporters, among other mechanisms. For instance, genetic variants in drug-metabolizing enzymes like cytochrome P450 enzymes can alter the rate at which drugs are metabolized, leading to differences in drug levels in the body.
Additionally, genetic variations in drug targets, such as receptors or enzymes, can affect a drug’s efficacy. Certain genetic variants may result in altered drug target structures, leading to variations in drug binding or activity. Moreover, variations in drug transporters can affect the absorption, distribution, and elimination of drugs.
Constructing a concept map can visually represent the relationship between pharmacogenomics and drug response in people with various illnesses. The map can include key elements such as genetic variations, drug metabolism, drug targets, drug transporters, drug efficacy, and drug toxicity. By connecting these elements, you can demonstrate how genetic factors impact the response to specific drugs in individuals with different illnesses.