Medications Affecting Coagulation

Please go through and fill out the table on Medications affecting Coagulation.

Medications Affecting Coagulation

	Coumadin	Heparin	Lovenox
Mode of Action
Indications
Dosage/Route
Side Effects
Labs to Monitor
Antidote
Patient teaching

Medications Affecting Coagulation

	Coumadin (Warfarin)	Heparin	Lovenox (Enoxaparin)
Mode of Action	Oral anticoagulant	Parenteral	Parenteral
Indications	– Prevention and	– Prevention and	– Prevention and
	treatment of	treatment of deep	treatment of deep
	venous thrombosis	vein thrombosis,	vein thrombosis,
	– Prevention of	pulmonary embolism,	pulmonary embolism,
	stroke in	atrial fibrillation,	atrial fibrillation,
	atrial fibrillation	and other	and other
	– Prevention of	hypercoagulable	hypercoagulable
	systemic embolism	conditions	conditions
Dosage/Route	Individualized oral	Subcutaneous or IV	Subcutaneous
	dosing
Side Effects	– Bleeding	– Bleeding	– Bleeding
	– Skin necrosis	– Heparin-induced	– Heparin-induced
	– Purple toes	thrombocytopenia	thrombocytopenia
	– Hair loss	– Osteoporosis	– Osteoporosis
	– Nausea, diarrhea	– Hyperkalemia	– Hyperkalemia
	– Rash	– Hypersensitivity	– Hypersensitivity
	– Elevated liver	– Elevated liver	– Elevated liver
	enzymes	enzymes	enzymes
Labs to Monitor	– International	– Activated partial	– Anti-factor Xa
	normalized ratio	thromboplastin time	activity
	(INR)	(aPTT)
	– Complete blood	– Platelet count
	count (CBC)	– aPTT
		– Hemoglobin and
		hematocrit
Antidote	Vitamin K (if	Protamine sulfate	Protamine sulfate
	necessary)	(for heparin)	(for enoxaparin)
Patient Teaching	– Take medication	– Educate on proper	– Educate on proper
	as prescribed and	administration of	administration of
	have regular INR	injections,	injections,
	monitoring	dosage, and timing	dosage, and timing
	– Be consistent	– Report any signs	– Report any signs
	with vitamin K-	of bleeding or	of bleeding or
	containing foods	heparin-induced	heparin-induced
	– Avoid excessive	thrombocytopenia	thrombocytopenia
	alcohol consumption	– Wear a medical	– Wear a medical
	– Inform healthcare	alert bracelet	alert bracelet
	provider of any	– Report any signs	– Report any signs
	changes in diet,	of allergic reactions	of allergic reactions
	medications, or
	other factors that
	may affect INR

Please note that this is a general overview, and specific recommendations and patient teaching should always be provided by a healthcare professional based on the patient’s unique condition and needs. Dosage and monitoring also vary depending on the individual patient’s condition.